Non-linear analysis of intracranial human EEG in temporal lobe epilepsy

Heyden, M.J.van der; Velis, D.N.; Hoekstra, B.P.T.; Pijn, J.P.M.; van Emde Boas, W.; van Veelen, C.W.M.; van Rijen, P.C.; Lopes da Silva, F.H.; DeGoede, J.

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Volume 110, Issue 10 , Pages 1726-1740, 1 October 1999

Non-linear analysis of intracranial human EEG in temporal lobe epilepsy

M.J.van der Heyden
- Department of Physiology, Leiden University, PO Box 9604, 2300 RC Leiden, The Netherlands
D.N. Velis
- Instituut voor Epilepsiebestrijding, ‘Meer en Bosch’/‘De Cruquiushoeve’, Heemstede, The Netherlands
B.P.T. Hoekstra
- Department of Physiology, Leiden University, PO Box 9604, 2300 RC Leiden, The Netherlands
J.P.M. Pijn
- Deceased.
- Instituut voor Epilepsiebestrijding, ‘Meer en Bosch’/‘De Cruquiushoeve’, Heemstede, The Netherlands
W. van Emde Boas
- Instituut voor Epilepsiebestrijding, ‘Meer en Bosch’/‘De Cruquiushoeve’, Heemstede, The Netherlands
C.W.M. van Veelen
- Department of Neurosurgery, University Hospital Utrecht, Utrecht, The Netherlands
P.C. van Rijen
- Department of Neurosurgery, University Hospital Utrecht, Utrecht, The Netherlands
F.H. Lopes da Silva
- Instituut voor Epilepsiebestrijding, ‘Meer en Bosch’/‘De Cruquiushoeve’, Heemstede, The Netherlands
J. DeGoede
- Department of Physiology, Leiden University, PO Box 9604, 2300 RC Leiden, The Netherlands
- Corresponding author. Tel.: +-31-71-527-67-83; fax: +31-71-527-67-82

Accepted 16 April 1999.

Abstract

Objective: Intracranial EEG recordings from patients suffering from medically intractable temporal lobe epilepsy were analyzed with the aim of characterizing the dynamics of EEG epochs recorded before and during a seizure and comparing the classification of the EEG epochs on the basis of visual inspection to the results of the numerical analysis.

Methods: The stationarity of the selected EEGs was assessed qualitatively. The coarse-grained correlation dimension and coarse-grained correlation entropy were used for the non-linear characterization of the EEG epochs.

Results: High-pass filtering was necessary in order to make the majority of the epochs appear stationarity beyond a time scale of about 2 s. It was found that the dimension of the ictal EEGs decreased with respect to the epochs containing ongoing (interictal) activity. The entropy of the ictal recordings however increased. A scaling of the entropy was applied and it was found that the scaled entropy of the ictal EEG decreased, consistent with the increased regularity of the ictal EEG. The coarse-grained quantities discriminated well between EEG epochs recorded prior to and during seizures at locations displaying ictal activity and classification improved by including the linear autocorrelation time in the analysis.

Conclusions: It is concluded that ictal and non-ictal EEG can be well distinguished on the basis of non-linear analysis. The results are in good agreement with the visual analysis.

Keywords: Temporal lobe epilepsy, Intracranial EEG, Stationarity, Non-linear analysis