Increased phase synchronization during continuous face integration measured simultaneously with EEG and fMRI

Abstract 

Objective

Gamma zero-lag phase synchronization has been measured in the animal brain during visual binding. Human scalp EEG studies used a phase locking factor (trial-to-trial phase-shift consistency) or gamma amplitude to measure binding but did not analyze common-phase signals so far. This study introduces a method to identify networks oscillating with near zero-lag phase synchronization in human subjects.

Methods

We presented unpredictably moving face parts (NOFACE) which – during some periods – produced a complete schematic face (FACE). The amount of zero-lag phase synchronization was measured using global field synchronization (GFS). GFS provides global information on the amount of instantaneous coincidences in specific frequencies throughout the brain.

Results

Gamma GFS was increased during the FACE condition. To localize the underlying areas, we correlated gamma GFS with simultaneously recorded BOLD responses. Positive correlates comprised the bilateral middle fusiform gyrus and the left precuneus.

Conclusions

These areas may form a network of areas transiently synchronized during face integration, including face-specific as well as binding-specific regions and regions for visual processing in general.

Significance

Thus, the amount of zero-lag phase synchronization between remote regions of the human visual system can be measured with simultaneously acquired EEG/fMRI.

Keywords: Gamma, Zero-lag phase synchronization, Multimodal imaging, Face, Visual binding