Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400☆
Accepted 4 July 2009.
Abstract
This paper describes recommended methods for the use of event-related brain potentials (ERPs) in clinical research and reviews applications to a variety of psychiatric and neurological disorders. Techniques are presented for eliciting, recording, and quantifying three major cognitive components with confirmed clinical utility: mismatch negativity (MMN), P300, and N400. Also highlighted are applications of each of the components as methods of investigating central nervous system pathology. The guidelines are intended to assist investigators who use ERPs in clinical research, in an effort to provide clear and concise recommendations and thereby to standardize methodology and facilitate comparability of data across laboratories.
aClinical Psychophysiology and Psychopharmacology Laboratory, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
bSchool of Psychology and Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia
cDepartment of Linguistics and Languages, McMaster University, Hamilton, Ont., Canada
dHospices Civils de Lyon, Neurological Hospital and INSERM U821, Lyon, France
eSchool of Psychology, The University of Newcastle, Callaghan, NSW, Australia
fDepartment of Psychology, University of Tartu, Tartu, Estonia
gCenter of Functionally Integrative Neuroscience (CFIN), University of Aarhus, Aarhus, Denmark
hCognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland
iCognitive Electrophysiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
jDepartment of Psychology, University of Oslo, Oslo, Norway
kDepartment of Psychology, Binghamton University, Binghamton, New York, USA
Corresponding author. Address: CPPL, Department of Psychiatry, USU, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. Tel.: +1 301 295 2288; fax: +1 301 564 9562.
☆ Order of authors, after the first author, is alphabetical.
ABSTRACT