Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Duncan, Connie C.; Barry, Robert J.; Connolly, John F.; Fischer, Catherine; Michie, Patricia T.; Näätänen, Risto; Polich, John; Reinvang, Ivar; Van Petten, Cyma

doi:10.1016/j.clinph.2009.07.045

« Previous Next »Clinical Neurophysiology
Volume 120, Issue 11 , Pages 1883-1908, November 2009

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400☆

Connie C. Duncan
- Clinical Psychophysiology and Psychopharmacology Laboratory, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
- Corresponding author. Address: CPPL, Department of Psychiatry, USU, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. Tel.: +1 301 295 2288; fax: +1 301 564 9562.
Robert J. Barry
- School of Psychology and Brain & Behaviour Research Institute, University of Wollongong, Wollongong, NSW, Australia
John F. Connolly
- Department of Linguistics and Languages, McMaster University, Hamilton, Ont., Canada
Catherine Fischer
- Hospices Civils de Lyon, Neurological Hospital and INSERM U821, Lyon, France
Patricia T. Michie
- School of Psychology, The University of Newcastle, Callaghan, NSW, Australia
Risto Näätänen
- Department of Psychology, University of Tartu, Tartu, Estonia
- Center of Functionally Integrative Neuroscience (CFIN), University of Aarhus, Aarhus, Denmark
- Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland
John Polich
- Cognitive Electrophysiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
Ivar Reinvang
- Department of Psychology, University of Oslo, Oslo, Norway
Cyma Van Petten
- Department of Psychology, Binghamton University, Binghamton, New York, USA

Accepted 4 July 2009.

Abstract

This paper describes recommended methods for the use of event-related brain potentials (ERPs) in clinical research and reviews applications to a variety of psychiatric and neurological disorders. Techniques are presented for eliciting, recording, and quantifying three major cognitive components with confirmed clinical utility: mismatch negativity (MMN), P300, and N400. Also highlighted are applications of each of the components as methods of investigating central nervous system pathology. The guidelines are intended to assist investigators who use ERPs in clinical research, in an effort to provide clear and concise recommendations and thereby to standardize methodology and facilitate comparability of data across laboratories.

Keywords: Event-related potentials, Mismatch negativity, MMN, P300, N400, Guidelines, Clinical investigations