Clinical Neurophysiology
Volume 120, Issue 11 , Pages 1881-1882 , November 2009

Corticomotoneuronal dysfunction: A process specific to amyotrophic lateral sclerosis?

  • Steve Vucic

      Affiliations

    • Corresponding Author InformationTel.: +61 2 9845 6097; fax: +61 2 9635 6684.

,Accepted 11 August 2009.

References 

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  2. Bostock H, Sharief MK, Reid G, Murray NM. Axonal ion channel dysfunction in amyotrophic lateral sclerosis. Brain. 1995;118:217–225
  3. Eisen A. Kennedy’s disease: a lower motor neuron model to identify upper motor neuron physiology in ALS. Clin Neurophysiol. 2008;119:971–972
  4. Hirota N, Eisen A, Weber M. Complex fasciculations and their origin in amyotrophic lateral sclerosis and Kennedy’s disease. Muscle Nerve. 2000;23:1872–1875
  5. Kanai K, Kuwabara S, Misawa S, Tamura N, Ogawara K, Nakata M, et al. Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stage. Brain. 2006;129:953–962
  6. Kennedy WR, Alter M, Sung JH. Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait. Neurology. 1968;18:671–680
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  9. Pachatz C, Terracciano C, Desiato MT, Orlacchio A, Mori F, Rocchi C, et al. Upper motor neuron involvement in X-linked recessive bulbospinal muscular atrophy. Clin Neurophysiol. 2007;118:262–268
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  11. Vucic S, Burke D, Kiernan MC. Diagnosis of motor neuron disease. In:  Kiernan MC editors. The motor neuron disease handbook.. Sydney: Australasian Medical Publishing Company Limited; 2007;p. 89–115
  12. Vucic S, Kiernan MC. Axonal excitability properties in amyotrophic lateral sclerosis. Clin Neurophysiol. 2006;117:1458–1466
  13. Vucic S, Kiernan MC. Novel threshold tracking techniques suggest that cortical hyperexcitability is an early feature of motor neuron disease. Brain. 2006;129:2436–2446
  14. Vucic S, Kiernan MC. Pathophysiological insights into motor axonal function in Kennedy’s disease. Neurology. 2007;69:1828–1835
  15. Vucic S, Kiernan MC. Cortical excitability testing distinguishes Kennedy’s disease from amyotrophic lateral sclerosis. Clin Neurophysiol. 2008;119:1088–1096
  16. Vucic S, Nicholson GA, Kiernan MC. Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis. Brain. 2008;131:1540–1550
  17. Weber M, Eisen A. Assessment of upper and lower motor neurons in Kennedy’s disease: implications for corticomotoneuronal PSTH studies. Muscle Nerve. 1999;22:299–306
  18. Weber M, Ferreira V, Eisen A. Determinants of double discharges in amyotrophic lateral sclerosis and Kennedy’s disease. Clin Neurophysiol. 2009;120:1971–1977

PII: S1388-2457(09)00496-9

doi: 10.1016/j.clinph.2009.08.010

Clinical Neurophysiology
Volume 120, Issue 11 , Pages 1881-1882 , November 2009

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