Clinical Neurophysiology
Volume 120, Issue 1 , Pages 93-107 , January 2009

Differential effects of 5-HTTLPR and DRD2/ANKK1 polymorphisms on electrocortical measures of error and feedback processing in children

  • Monika Althaus

      Affiliations

    • Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 50 3681103; fax: +31 50 3618122.
    • ,
  • Yvonne Groen

      Affiliations

    • Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    • ,
  • Albertus A. Wijers

      Affiliations

    • Department of Experimental and Work Psychology, University of Groningen, Groningen, The Netherlands
    • ,
  • Lambertus J.M. Mulder

      Affiliations

    • Department of Experimental and Work Psychology, University of Groningen, Groningen, The Netherlands
    • ,
  • Ruud B. Minderaa

      Affiliations

    • Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    • ,
  • Ido P. Kema

      Affiliations

    • Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Janneke D.A. Dijck

      Affiliations

    • Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • ,
  • Catharina A. Hartman

      Affiliations

    • Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    • ,
  • Pieter J. Hoekstra

      Affiliations

    • Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

,Accepted 11 October 2008.

  • Image Result

    Time course of a single trial. Within one task block each trial started with the presentation of one out of four stimuli. The feedback stimulus appeared 1000ms after stimulus off-set and stayed on the

    Time course of a single trial. Within one task block each trial started with the presentation of one out of four stimuli. The feedback stimulus appeared 1000ms after stimulus off-set and stayed on the screen for 1500ms. The next trial started after a variable Inter Trial Interval (ITI) of 500, 750, or 1000ms. Originally published in Groen et al. (2007).

  • Image Result
    ERN time-locked to the response (0ms) at Fz. ERPs are depicted for both the first and second half of the task and correct and incorrect responses: (a) 5-HTTLPR S carriers; (b) homozygous 5-HTTLPR L ca

    ERN time-locked to the response (0ms) at Fz. ERPs are depicted for both the first and second half of the task and correct and incorrect responses: (a) 5-HTTLPR S carriers; (b) homozygous 5-HTTLPR L carriers; (c) DRD2 Taq1 A1 carriers; (d) DRD2 Taq1 A1 non-carriers; (e) carriers of both the 5-HTTLPR S variant and the Taq1 A1 allele of the DRD2 gene; and (f) carriers of neither the 5-HTTLPR S variant nor the Taq1 A1 allele of the DRD2 gene.

  • Image Result
    Pe time-locked to the response (0ms) at Pz. ERPs are depicted for both the first and second half of the task and correct and incorrect responses: (a) 5-HTTLPR S carriers; (b) homozygous 5-HTTLPR L car

    Pe time-locked to the response (0ms) at Pz. ERPs are depicted for both the first and second half of the task and correct and incorrect responses: (a) 5-HTTLPR S carriers; (b) homozygous 5-HTTLPR L carriers; (c) DRD2 Taq1 A1 carriers; (d) DRD2 Taq1 A1 non-carriers; (e) carriers of both the 5-HTTLPR S variant and the Taq1 A1 allele of the DRD2 gene; and (f) carriers of neither the 5-HTTLPR S variant nor the Taq1 A1 allele of the DRD2 gene.

  • Image Result
    P3 and LPP time-locked to the feedback stimulus (0ms) at Pz. ERPs are depicted for both the first and second half of the task and positive and negative feedback: (a) 5-HTTLPR S carriers; (b) homozygou

    P3 and LPP time-locked to the feedback stimulus (0ms) at Pz. ERPs are depicted for both the first and second half of the task and positive and negative feedback: (a) 5-HTTLPR S carriers; (b) homozygous 5-HTTLPR L carriers; (c) DRD2 Taq1 A1 carriers; (d) DRD2 Taq1 A1 non-carriers; (e) carriers of both the 5-HTTLPR S variant and the Taq1 A1 allele of the DRD2 gene; (f) carriers of neither the 5-HTTLPR S variant nor the Taq1 A1 allele of the DRD2 gene.

  • Image Result
    Mean amplitudes (with standard errors) of the intervals that turned out to contain significant group by task variable effects. (a)–(c) reflect the group interactions found for the response-locked ERN

    Mean amplitudes (with standard errors) of the intervals that turned out to contain significant group by task variable effects. (a)–(c) reflect the group interactions found for the response-locked ERN and Pe. (d)–(i) reflect the interactions found for the feedback-locked P3 and LPP.

PII: S1388-2457(08)01018-3

doi: 10.1016/j.clinph.2008.10.012

Clinical Neurophysiology
Volume 120, Issue 1 , Pages 93-107 , January 2009

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