Clinical Neurophysiology
Volume 120, Issue 1 , Pages 80-84 , January 2009

Bilateral frontal transcranial direct current stimulation: Failure to replicate classic findings in healthy subjects

  • Michael Koenigs

      Affiliations

    • Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1440, Bethesda, MD 20892-1440, USA
    • Department of Psychiatry, University of Wisconsin – Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
  • ,
  • Dede Ukueberuwa

      Affiliations

    • Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1440, Bethesda, MD 20892-1440, USA
  • ,
  • Paul Campion

      Affiliations

    • Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1440, Bethesda, MD 20892-1440, USA
  • ,
  • Jordan Grafman

      Affiliations

    • Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1440, Bethesda, MD 20892-1440, USA
  • ,
  • Eric Wassermann

      Affiliations

    • Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1440, Bethesda, MD 20892-1440, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 301 496 0151; fax: +1 301 480 2909.

,Accepted 6 October 2008.

References 

  1. Barrash J, Tranel D, Anderson SW. Acquired personality disturbances associated with bilateral damage to the ventromedial prefrontal region. Dev Neuropsychol. 2000;18(3):355–381
  2. Bechara A, Damasio H, Tranel D, Damasio AR. Deciding advantageously before knowing the advantageous strategy. Science. 1997;275(5304):1293–1295
  3. Been G, Ngo TT, Miller SM, Fitzgerald PB. The use of tDCS and CVS as methods of non-invasive brain stimulation. Brain Res Rev. 2007;56(2):346–361
  4. Boggio PS, Nunes A, Rigonatti SP, Nitsche MA, Pascual-Leone A, Fregni F. Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients. Restor Neurol Neurosci. 2007;25(2):123–129
  5. Boggio PS, Rigonatti SP, Ribeiro RB, Myczkowski ML, Nitsche MA, Pascual-Leone A, et al. A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. Int J Neuropsychopharmacol. 2008;11(2):249–254
  6. Boggio PS, Sultani N, Fecteau S, Merabet L, Mecca T, Pascual-Leone A, et al. Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: a double-blind, sham-controlled study. Drug Alcohol Depend. 2008;92(1–3):55–60
  7. Carney MW, Cashman MD, Sheffield BF. Polarization in depression. Br J Psychiatry. 1970;117(539):474–475
  8. Costain R, Redfearn JW, Lippold OC. A controlled trial of the therapeutic effect of polarization of the brain in depressive illness. Br J Psychiatry. 1964;110:786–799
  9. Fecteau S, Knoch D, Fregni F, Sultani N, Boggio P, Pascual-Leone A. Diminishing risk-taking behavior by modulating activity in the prefrontal cortex: a direct current stimulation study. J Neurosci. 2007;27(46):12500–12505
  10. Fecteau S, Pascual-Leone A, Zald DH, Liguori P, Theoret H, Boggio PS, et al. Activation of prefrontal cortex by transcranial direct current stimulation reduces appetite for risk during ambiguous decision making. J Neurosci. 2007;27(23):6212–6218
  11. Ferrucci R, Mameli F, Guidi I, Mrakic-Sposta S, Vergari M, Marceglia S, et al. Transcranial direct current stimulation improves recognition memory in Alzheimer disease. Neurology. 2008;71:493–498
  12. Fregni F, Pascual-Leone A. Technology insight: noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS. Nat Clin Pract Neurol. 2007;3(7):383–393
  13. Fregni F, Boggio PS, Nitsche M, Bermpohl F, Antal A, Feredoes E, et al. Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Exp Brain Res. 2005;166(1):23–30
  14. Fregni F, Boggio PS, Nitsche MA, Marcolin MA, Rigonatti SP, Pascual-Leone A. Treatment of major depression with transcranial direct current stimulation. Bipolar Disord. 2006;8(2):203–204
  15. Fregni F, Orsati F, Pedrosa W, Fecteau S, Tome FA, Nitsche MA, et al. Transcranial direct current stimulation of the prefrontal cortex modulates the desire for specific foods. Appetite. 2007;
  16. Fregni F, Liguori P, Fecteau S, Nitsche MA, Pascual-Leone A, Boggio PS. Cortical stimulation of the prefrontal cortex with transcranial direct current stimulation reduces cue-provoked smoking craving: a randomized, sham-controlled study. J Clin Psychiatry. 2008;69(1):32–40
  17. Gandiga PC, Hummel FC, Cohen LG. Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clin Neurophysiol. 2006;117(4):845–850
  18. George MS, Wassermann EM, Williams WA, Steppel J, Pascual-Leone A, Basser P, et al. Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation (rTMS) of the prefrontal cortex. J Neuropsychiatry Clin Neurosci. 1996;8:172–180
  19. Herjanic M, Moss-Herjanic B. Clinical report on a new therapeutic technique: polarization. Can Psychiatr Assoc J. 1967;12(4):423–424
  20. Iyer MB, Mattu U, Grafman J, Lomarev M, Sato S, Wassermann EM. Safety and cognitive effect of frontal DC brain polarization in healthy individuals. Neurology. 2005;64(5):872–875
  21. Kincses TZ, Antal A, Nitsche MA, Bartfai O, Paulus W. Facilitation of probabilistic classification learning by transcranial direct current stimulation of the prefrontal cortex in the human. Neuropsychologia. 2004;42(1):113–117
  22. Koenigs M, Young L, Adolphs R, Tranel D, Cushman F, Hauser M, et al. Damage to the prefrontal cortex increases utilitarian moral judgements. Nature. 2007;446(7138):908–911
  23. Lang PJ, Bradley MM, Cuthbert BN. International affective picture system (IAPS): Instruction manual and affective ratings, The Center for Research in Psychophysiology, University of Florida; 2001.
  24. Lippold OC, Redfearn JW. Mental changes resulting from the passage of small direct currents through the human brain. Br J Psychiatry. 1964;110:768–772
  25. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, et al. Deep brain stimulation for treatment-resistant depression. Neuron. 2005;45(5):651–660
  26. McNair DM, Lorr M, Droppleman LF. Edits manual for the Profile of Mood States (revised edition). San Diego (CA): Educational and Industrial Testing Service; 1992;
  27. Miller EN. California Computerized Assessment Battery (CalCAP) Manual. Neurology. Los Angeles: Software; 1990.
  28. Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000;527(Pt 3):633–639
  29. Pascual-Leone A, Catalá MD, Pascual-Leone A. Lateralized effect of rapid-rate transcranial magnetic stimulation of the prefrontal cortex on mood. Neurology. 1996;46:499–502
  30. Purpura DP, McMurtry JG. Intacellular activities and evoked potential changes during polarization of motor cortex. J Neurophysiol. 1964;18(1):166–185
  31. Ramsay JC, Schlagenhauf G. Treatment of depression with low voltage direct current. South Med J. 1966;59(8):932–934
  32. Sheffield LJ, Mowbray RM. The effects of polarization on normal subjects. Br J Psychiatry. 1968;114(507):225–232

PII: S1388-2457(08)01016-X

doi: 10.1016/j.clinph.2008.10.010

Clinical Neurophysiology
Volume 120, Issue 1 , Pages 80-84 , January 2009