Differentiating phase shift and delay in narrow band coherent signals

Muthuraman, M.; Govindan, R.B.; Deuschl, G.; Heute, U.; Raethjen, J.

doi:10.1016/j.clinph.2008.01.003

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Volume 119, Issue 5 , Pages 1062-1070, May 2008

Differentiating phase shift and delay in narrow band coherent signals

M. Muthuraman
- Institute for Circuit and System Theory, Faculty of Engineering, University of Kiel, Kaiserstrasse 2, D-24143 Kiel, Germany
- Department of Neurology, University of Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
R.B. Govindan
- Department of Neurology, University of Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
- Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
G. Deuschl
- Department of Neurology, University of Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
U. Heute
- Institute for Circuit and System Theory, Faculty of Engineering, University of Kiel, Kaiserstrasse 2, D-24143 Kiel, Germany
J. Raethjen
- Department of Neurology, University of Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
- Corresponding author. Tel.: +49 (0) 431 597 8515; fax: +49 (0) 431 597 8502.

Accepted 10 January 2008.

Abstract

Objective

Differentiating between a fixed activation pattern (phase shift) and conduction time (time delay) in rhythmic signals has important physiological implications but is methodologically difficult.

Methods

Delay was estimated by the maximising coherence method and phase spectra calculated between (i) a narrow band-pass filtered AR2 process and its delayed copy for different phase shifts, (ii) the surface EMGs from two antagonistic forearm muscles with reciprocal alternating activity, and (iii) EEG and EMG data from 11 recordings in five Parkinsonian tremor patients.

Results

Estimated delays between the versions of the AR2 process resembled the real delay and were not significantly biased by the phase-shifts. The reciprocal alternating pattern of muscle activation was shown to be a pure phase-shift without any time delay. The phase between tremor-coherent cortical electrodes and EMG showed opposite signs and differed by 3π/4−π between the antagonistic muscles. Bidirectional delays between contralateral cortex and EMG did not differ between the antagonists and were in keeping with fast corticospinal transmission and feedback to the cortex for both muscles.