Effects of 5-hydroxytryptophan on the sleep of normal human subjectsEffets du 5-hydroxytryptophane sur le sommeil de sujets normaux
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Cited by (57)
The neurobiological basis of sleep: Insights from Drosophila
2018, Neuroscience and Biobehavioral ReviewsCitation Excerpt :However, pharmacological manipulations of serotonergic signaling have demonstrated effects on sleep and wake in similar ways that have been seen in Drosophila. For example, injecting p-chlorophenylalanine – an inhibitor of serotonin synthesis – into the dorsal raphe nucleus acutely induces insomnia in rats (Gao et al., 2002) and early experiments in humans found that administration of the serotonin precursor 5-HTP increases REM sleep duration, though total sleep is not affected (Wyatt et al., 1971). Additionally, some antidepressant serotonin reuptake and serotonin receptor subtype inhibitors have been linked to improvements in subjective and objective sleep quality in depressed and non-depressed patients (Reviewed in Wilson and Argyropoulos, 2005).
Alternative Therapeutics for Sleep Disorders
2012, Therapy in Sleep MedicineThe effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats
2004, Journal of Chemical NeuroanatomySafety of 5-hydroxy-L-tryptophan
2004, Toxicology LettersAnorexia and altered serotonin metabolism in a patient with argininosuccinic aciduria
1986, The Journal of Pediatrics
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Present address: National Heart Institute, 9000 Rockville Pike, Bethesda, Md. 20014, U.S.A.