Thyroid hormone and brain function: I. The EEG in hyperthyroidism with observations on the effect of age, sex, and reserpine in the production of abnormalities

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Abstract

Pretreatment EEGs were obtained on 81 hyperthyroid patients. In order to study the effects of sex and the menopause on the incidence of EEG abnormalities, the patients were divided into three groups: 1. premenopausal females, 2. postmenopausal females, and 3. males. The highest incidence of abnormalities was found in premenopausal females, and the lowest incidence in postmenopausal females.

The administration of reserpine to thyrotoxic patients increased the incidence of EEG abnormalities.

Most of the records obtained 3 months to 1 year after specific antithyroid treatment with radioactive iodine were normal except for the persistence of high voltage photic responses.

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This work was supported by a grant from the Hogg Foundation for Mental Health of the University of Texas.

2

Associate Professor of Psychiatry and Director of Psychiatric Research. Present address: Box 3355, Duke University Medical Center, Durham, N.C. (U.S.A.).

3

Assistant Professor of Medicine.

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